| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 26°F | 48°F | 36°F | 3.8" |
| February | 28°F | 52°F | 39°F | 3.1" |
| March | 36°F | 63°F | 48°F | 4.2" |
| April | 44°F | 73°F | 58°F | 4.4" |
| May | 53°F | 79°F | 65°F | 4.1" |
| June | 60°F | 87°F | 73°F | 3.3" |
| July | 65°F | 88°F | 75°F | 6.5" |
| August | 63°F | 87°F | 74°F | 4.8" |
| September | 57°F | 82°F | 68°F | 3.1" |
| October | 45°F | 72°F | 57°F | 3.2" |
| November | 33°F | 61°F | 46°F | 2.8" |
| December | 31°F | 52°F | 40°F | 4.6" |
| Index | Wise | Virginia | National |
| Air quality index | 45 | 58 | 42 |
| Pollution index | 68,075 | 1,561,881 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 236 |
| Days with moderate air quality | 108 |
| Days w/ poor A.Q. for sensitive groups | 21 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.002% |
| Benzene | 0.001% |
| Carbon Tetrachloride | 0.000% |
| Lead | 0.001% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Dungannon, VA | 302 | 45 | 10.0% |
| Jenkins, KY | 1,815 | 45 | 10.0% |
| Pound, VA | 972 | 45 | 10.0% |
| Appalachia, VA | 1,400 | 45 | 10.0% |
| Mayking, KY | 513 | 45 | 10.0% |
| Wise, VA | 2,954 | 45 | 10.0% |
| City | Population | Air Quality Index | National Avg. |
| Groveville, NJ | 2,953 | 41 | 18.0% |
| Allendale, SC | 2,953 | 29 | 42.0% |
| Edgewood, FL | 2,955 | 39 | 22.0% |
| Shenandoah, TX | 2,955 | 52 | 4.0% |
| Greensboro, AL | 2,956 | 35 | 30.0% |
| Wise, VA | 2,954 | 45 | 10.0% |
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