| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 27°F | 43°F | 34°F | 8.8" |
| February | 28°F | 45°F | 36°F | 4.2" |
| March | 36°F | 55°F | 44°F | 4.0" |
| April | 45°F | 64°F | 54°F | 5.8" |
| May | 52°F | 70°F | 61°F | 7.3" |
| June | 60°F | 78°F | 69°F | 6.0" |
| July | 62°F | 79°F | 70°F | 7.5" |
| August | 61°F | 77°F | 69°F | 5.1" |
| September | 56°F | 72°F | 63°F | 11.0" |
| October | 46°F | 63°F | 54°F | 12.0" |
| November | 36°F | 54°F | 44°F | 6.3" |
| December | 32°F | 48°F | 39°F | 4.6" |
| Index | Wilkesboro | North Carolina | National |
| Air quality index | 26 | 35 | 42 |
| Pollution index | 3,428,900 | 2,789,538 | 2,726,193 |
| Measurement | Total |
| Days measured | 122 |
| Days with good air quality | 109 |
| Days with moderate air quality | 12 |
| Days w/ poor A.Q. for sensitive groups | |
| Days with unhealthy air quality | 1 |
| Pollutant | Total |
| Arsenic | 0.005% |
| Benzene | 0.030% |
| Carbon Tetrachloride | 0.010% |
| Lead | 0.010% |
| Mercury | 0.010% |
| City | Population | Air Quality Index | National Avg. |
| Millers Creek, NC | 1,461 | 26 | 48.0% |
| Hays, NC | 1,360 | 26 | 48.0% |
| Mulberry, NC | 2,055 | 26 | 48.0% |
| Cricket, NC | 2,453 | 26 | 48.0% |
| North Wilkesboro, NC | 4,139 | 26 | 48.0% |
| Wilkesboro, NC | 3,457 | 26 | 48.0% |
| City | Population | Air Quality Index | National Avg. |
| Gravette, AR | 3,456 | 44 | 12.0% |
| Pawhuska, OK | 3,456 | 40 | 20.0% |
| Elm Creek, TX | 3,455 | 25 | 50.0% |
| Virden, MB | 3,455 | n/a | |
| Seymour, WI | 3,459 | 37 | 26.0% |
| Wilkesboro, NC | 3,457 | 26 | 48.0% |
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