| Statistic | Upton | Kentucky | National |
| Population | 539 | 4,467,673 | 328,239,523 |
| Population density (sq mi) | 397 | 114 | 91 |
| Median age | 42.1 | 38.6 | 37.7 |
| Male/Female ratio | 1.1:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 66% | 58% | 55% |
| Families w/ Kids under 18 | 45% | 42% | 43% |
| Speak English | 100% | 95% | 79% |
| Speak Spanish | 0% | 3% | 13% |
| Race | Upton | Kentucky | National |
| White | 93.14% | 87.48% | 73.35% |
| Black | 4.27% | 7.94% | 12.63% |
| Asian | 0.00% | 1.29% | 5.22% |
| American Indian | 0.37% | 0.21% | 0.82% |
| Native Hawaiian | 0.00% | 0.06% | 0.18% |
| Mixed race | 2.23% | 2.10% | 3.06% |
| Other race | 0.00% | 0.92% | 4.75% |
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