| Index | South San Francisco | California | National |
| Average Test Scores | 42% | 43% | 48% |
| Student/Teacher ratio | 21:1 | 20:1 | 16:1 |
| Total public schools | 12 | 8,308 | 79,221 |
| Total private schools | 4 | 3,438 | 24,874 |
| Total post-secondary schools | 1 | 1,085 | 7,963 |
| Index | South San Francisco | California | National |
| Completed 8th grade | 83.3% | 81.1% | 84.3% |
| Completed high school | 82.2% | 79.8% | 83.0% |
| Completed some college | 63.2% | 61.5% | 59.4% |
| Completed associate degree | 41.7% | 39.8% | 38.5% |
| Completed bachelors | 32.5% | 32.0% | 30.3% |
| Completed masters | 7.2% | 11.9% | 11.5% |
| Completed professional degree | 2.0% | 3.9% | 3.3% |
| Completed doctorate | 0.5% | 1.6% | 1.3% |
There are a total of 12 public schools, 4 private schools and 1 post-secondary schools in South San Francisco. Using the proficiency score averages, the average test scores for South San Francisco, CA schools is 42%. The average student to teacher ratio is 21:1. In South San Francisco, CA, an average of 83.3% of students have completed 8th grade and an average of 82.2% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Hillsborough, CA | 11,608 | 86% | 78.4% |
| Moraga, CA | 16,896 | 84% | 75.2% |
| Palo Alto, CA | 67,973 | 81% | 68.5% |
| Belmont, CA | 26,963 | 79% | 65.5% |
| Burlingame, CA | 30,071 | 79% | 65.0% |
| South San Francisco, CA | 66,878 | 42% | 12.9% |
| City | Population | Avg. Test Scores | National Avg. |
| Johnson City, TN | 66,934 | 52% | 8.9% |
| Victoria, TX | 66,974 | 36% | 25.2% |
| Lehi, UT | 66,980 | 52% | 8.4% |
| Conway, AR | 66,776 | 58% | 20.7% |
| Kenner, LA | 66,759 | 65% | 34.8% |
| South San Francisco, CA | 66,878 | 42% | 12.9% |
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