| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 37°F | 60°F | 47°F | 3.0" |
| February | 38°F | 62°F | 49°F | 3.8" |
| March | 45°F | 71°F | 57°F | 3.0" |
| April | 53°F | 78°F | 65°F | 3.2" |
| May | 60°F | 84°F | 72°F | 3.5" |
| June | 69°F | 91°F | 79°F | 4.4" |
| July | 71°F | 93°F | 80°F | 6.1" |
| August | 72°F | 91°F | 80°F | 4.3" |
| September | 66°F | 87°F | 75°F | 3.9" |
| October | 54°F | 78°F | 65°F | 3.8" |
| November | 43°F | 68°F | 54°F | 2.7" |
| December | 41°F | 63°F | 51°F | 4.2" |
| Index | Santee | South Carolina | National |
| Air quality index | 29 | 37 | 42 |
| Pollution index | 783,589 | 3,620,438 | 2,726,193 |
| Measurement | Total |
| Days measured | 7 |
| Days with good air quality | 7 |
| Days with moderate air quality | 0 |
| Days w/ poor A.Q. for sensitive groups | 0 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.001% |
| Benzene | 0.010% |
| Carbon Tetrachloride | 0.001% |
| Lead | 0.003% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Holly Hill, SC | 1,469 | 29 | 42.0% |
| Vance, SC | 102 | 29 | 42.0% |
| Eutawville, SC | 515 | 29 | 42.0% |
| Bowman, SC | 617 | 29 | 42.0% |
| Cameron, SC | 338 | 43 | 14.0% |
| Santee, SC | 1,165 | 29 | 42.0% |
| City | Population | Air Quality Index | National Avg. |
| Rodney Village, DE | 1,165 | 42 | 16.0% |
| Chisholm, ME | 1,165 | 28 | 44.0% |
| LaBarque Creek, MO | 1,165 | 54 | 8.0% |
| Southmont, NC | 1,165 | 40 | 20.0% |
| Wolfhurst, OH | 1,165 | 39 | 22.0% |
| Santee, SC | 1,165 | 29 | 42.0% |
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