| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 45°F | 69°F | 56°F | 2.3" |
| February | 46°F | 69°F | 56°F | 2.5" |
| March | 48°F | 71°F | 58°F | 1.2" |
| April | 50°F | 73°F | 61°F | 0.7" |
| May | 55°F | 74°F | 63°F | 0.5" |
| June | 59°F | 78°F | 67°F | 0.0" |
| July | 63°F | 82°F | 71°F | 0.3" |
| August | 64°F | 83°F | 72°F | 0.0" |
| September | 62°F | 84°F | 71°F | 0.2" |
| October | 56°F | 81°F | 67°F | 0.5" |
| November | 50°F | 76°F | 61°F | 1.0" |
| December | 45°F | 69°F | 55°F | 2.8" |
| Index | Santee | California | National |
| Air quality index | 64 | 55 | 42 |
| Pollution index | 162,740 | 10,473,190 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 87 |
| Days with moderate air quality | 253 |
| Days w/ poor A.Q. for sensitive groups | 23 |
| Days with unhealthy air quality | 2 |
| Pollutant | Total |
| Arsenic | 0.000% |
| Benzene | 0.003% |
| Carbon Tetrachloride | 0.000% |
| Lead | 0.000% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Bonita, CA | 12,470 | 64 | 28.0% |
| La Presa, CA | 37,410 | 64 | 28.0% |
| Spring Valley CDP (Lake County), CA | 1,154 | 64 | 28.0% |
| Casa de Oro-Mount Helix, CA | 19,327 | 64 | 28.0% |
| Granite Hills, CA | 4,020 | 64 | 28.0% |
| Santee, CA | 57,407 | 64 | 28.0% |
| City | Population | Air Quality Index | National Avg. |
| Midwest City, OK | 57,392 | 48 | 4.0% |
| Richland, WA | 57,353 | 37 | 26.0% |
| Bradenton, FL | 57,346 | 38 | 24.0% |
| Hanford, CA | 57,339 | 56 | 12.0% |
| Taunton, MA | 57,327 | 44 | 12.0% |
| Santee, CA | 57,407 | 64 | 28.0% |
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