| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 11°F | 39°F | 24°F | 0.4" |
| February | 13°F | 42°F | 26°F | 0.9" |
| March | 24°F | 56°F | 38°F | 1.3" |
| April | 33°F | 64°F | 47°F | 2.6" |
| May | 43°F | 74°F | 58°F | 3.9" |
| June | 54°F | 85°F | 69°F | 4.4" |
| July | 60°F | 93°F | 76°F | 2.7" |
| August | 58°F | 89°F | 73°F | 2.7" |
| September | 48°F | 82°F | 64°F | 1.8" |
| October | 35°F | 67°F | 49°F | 1.6" |
| November | 22°F | 55°F | 36°F | 0.4" |
| December | 11°F | 38°F | 23°F | 0.6" |
| Index | Mission | South Dakota | National |
| Air quality index | 44 | 36 | 42 |
| Pollution index | 167,591 | 345,623 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 274 |
| Days with moderate air quality | 87 |
| Days w/ poor A.Q. for sensitive groups | 4 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.000% |
| Benzene | 0.003% |
| Carbon Tetrachloride | 0.001% |
| Lead | 0.000% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| St. Francis, SD | 533 | 44 | 12.0% |
| Wood, SD | 55 | 44 | 12.0% |
| Antelope, SD | 780 | 44 | 12.0% |
| Soldier Creek, SD | 525 | 44 | 12.0% |
| Okreek, SD | 221 | 44 | 12.0% |
| Mission, SD | 1,408 | 44 | 12.0% |
| City | Population | Air Quality Index | National Avg. |
| Callahan, FL | 1,408 | 43 | 14.0% |
| Schuylerville, NY | 1,408 | 35 | 30.0% |
| Continental, OH | 1,408 | 39 | 22.0% |
| Apollo, PA | 1,408 | 38 | 24.0% |
| Crooks, SD | 1,408 | 36 | 28.0% |
| Mission, SD | 1,408 | 44 | 12.0% |
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