| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 21°F | 44°F | 31°F | 2.0" |
| February | 23°F | 47°F | 33°F | 2.1" |
| March | 35°F | 61°F | 46°F | 3.0" |
| April | 44°F | 71°F | 57°F | 5.7" |
| May | 53°F | 78°F | 65°F | 4.3" |
| June | 63°F | 87°F | 75°F | 4.8" |
| July | 67°F | 90°F | 78°F | 5.1" |
| August | 65°F | 89°F | 76°F | 3.9" |
| September | 57°F | 82°F | 69°F | 4.8" |
| October | 45°F | 71°F | 57°F | 3.9" |
| November | 35°F | 59°F | 46°F | 2.4" |
| December | 25°F | 45°F | 34°F | 2.7" |
| Index | Middletown | Missouri | National |
| Air quality index | 38 | 97 | 42 |
| Pollution index | 732,008 | 1,630,255 | 2,726,193 |
| Measurement | Total |
| Days measured | 245 |
| Days with good air quality | 239 |
| Days with moderate air quality | 6 |
| Days w/ poor A.Q. for sensitive groups | 0 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.001% |
| Benzene | 0.020% |
| Carbon Tetrachloride | 0.001% |
| Lead | 0.000% |
| Mercury | 0.000% |
| City | Population | Air Quality Index | National Avg. |
| Truxton, MO | 144 | 38 | 24.0% |
| Farber, MO | 406 | 38 | 24.0% |
| Montgomery City, MO | 2,659 | 38 | 24.0% |
| Wellsville, MO | 1,149 | 38 | 24.0% |
| Laddonia, MO | 579 | 38 | 24.0% |
| Middletown, MO | 216 | 38 | 24.0% |
| City | Population | Air Quality Index | National Avg. |
| Morrison Crossroads, AL | 216 | 38 | 24.0% |
| Defiance, IA | 216 | 40 | 20.0% |
| Cypress, IL | 216 | 44 | 12.0% |
| Rantoul, KS | 216 | 41 | 18.0% |
| Fountain, MI | 216 | 36 | 28.0% |
| Middletown, MO | 216 | 38 | 24.0% |
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