| Statistic | Mekoryuk | Alaska | National |
| Population | 262 | 731,545 | 328,239,523 |
| Population density (sq mi) | 37 | 1 | 91 |
| Median age | 39.0 | 33.6 | 37.7 |
| Male/Female ratio | 1.2:1 | 1.1:1 | 1.0:1 |
| Married (15yrs & older) | 41% | 53% | 55% |
| Families w/ Kids under 18 | 41% | 48% | 43% |
| Speak English | 31% | 84% | 79% |
| Speak Spanish | 0% | 4% | 13% |
| Race | Mekoryuk | Alaska | National |
| White | 0.00% | 65.62% | 73.35% |
| Black | 0.00% | 3.32% | 12.63% |
| Asian | 0.00% | 6.00% | 5.22% |
| American Indian | 97.33% | 14.06% | 0.82% |
| Native Hawaiian | 0.00% | 1.20% | 0.18% |
| Mixed race | 2.67% | 8.46% | 3.06% |
| Other race | 0.00% | 1.34% | 4.75% |
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