| Index | Mayo | Florida | National |
| Average Test Scores | 66% | 55% | 48% |
| Student/Teacher ratio | 14:1 | 17:1 | 16:1 |
| Total public schools | 2 | 3,388 | 79,221 |
| Total private schools | n/a | 1,640 | 24,874 |
| Total post-secondary schools | n/a | 466 | 7,963 |
| Index | Mayo | Florida | National |
| Completed 8th grade | 56.5% | 84.0% | 84.3% |
| Completed high school | 56.5% | 83.0% | 83.0% |
| Completed some college | 28.7% | 58.0% | 59.4% |
| Completed associate degree | 7.0% | 37.4% | 38.5% |
| Completed bachelors | 4.9% | 27.9% | 30.3% |
| Completed masters | 0.0% | 10.0% | 11.5% |
| Completed professional degree | 0.0% | 3.1% | 3.3% |
| Completed doctorate | 0.0% | 1.1% | 1.3% |
There are a total of 2 public schools, n/a private schools and n/a post-secondary schools in Mayo. Using the proficiency score averages, the average test scores for Mayo, FL schools is 66%. The average student to teacher ratio is 14:1. In Mayo, FL, an average of 56.5% of students have completed 8th grade and an average of 56.5% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Mayo, FL | 1,526 | 66% | 36.5% |
| City | Population | Avg. Test Scores | National Avg. |
| New Market, MD | 1,527 | 64% | 32.6% |
| Valatie, NY | 1,525 | 68% | 42.4% |
| Plentywood, MT | 1,527 | 40% | 17.0% |
| Limestone, ME | 1,527 | 62% | 29.7% |
| Moody, TX | 1,525 | 40% | 17.7% |
| Mayo, FL | 1,526 | 66% | 36.5% |
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