| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 55°F | 76°F | 64°F | 3.0" |
| February | 56°F | 78°F | 66°F | 1.9" |
| March | 59°F | 81°F | 69°F | 2.3" |
| April | 64°F | 86°F | 75°F | 2.2" |
| May | 69°F | 90°F | 79°F | 3.2" |
| June | 74°F | 91°F | 81°F | 9.9" |
| July | 75°F | 92°F | 82°F | 10.4" |
| August | 76°F | 92°F | 82°F | 10.7" |
| September | 74°F | 91°F | 81°F | 9.1" |
| October | 69°F | 87°F | 77°F | 4.0" |
| November | 61°F | 82°F | 70°F | 1.5" |
| December | 59°F | 79°F | 68°F | 1.8" |
| Index | Matlacha Isles-Matlacha Shores | Florida | National |
| Air quality index | 36 | 35 | 42 |
| Pollution index | 58,201,700 | 7,570,785 | 2,726,193 |
| Measurement | Total |
| Days measured | 365 |
| Days with good air quality | 328 |
| Days with moderate air quality | 36 |
| Days w/ poor A.Q. for sensitive groups | 1 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.001% |
| Benzene | 1.330% |
| Carbon Tetrachloride | 0.002% |
| Lead | 0.010% |
| Mercury | 0.001% |
| City | Population | Air Quality Index | National Avg. |
| Cape Coral, FL | 189,633 | 36 | 28.0% |
| Fort Myers Beach, FL | 7,102 | 36 | 28.0% |
| McGregor, FL | 7,899 | 36 | 28.0% |
| Punta Rassa, FL | 1,566 | 36 | 28.0% |
| Villas, FL | 14,421 | 36 | 28.0% |
| Matlacha Isles-Matlacha Shores, FL | 339 | 36 | 28.0% |
| City | Population | Air Quality Index | National Avg. |
| Mitchellville, AR | 339 | 43 | 14.0% |
| Vineland, CO | 339 | 20 | 60.0% |
| McIntosh, FL | 339 | 35 | 30.0% |
| Keysville, GA | 339 | 47 | 6.0% |
| Lacona, IA | 339 | 39 | 22.0% |
| Matlacha Isles-Matlacha Shores, FL | 339 | 36 | 28.0% |
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