| Statistic | Mathiston | Mississippi | National |
| Population | 652 | 2,976,149 | 328,239,523 |
| Population density (sq mi) | 261 | 64 | 91 |
| Median age | 37.4 | 36.7 | 37.7 |
| Male/Female ratio | 0.8:1 | 0.9:1 | 1.0:1 |
| Married (15yrs & older) | 64% | 54% | 55% |
| Families w/ Kids under 18 | 40% | 42% | 43% |
| Speak English | 100% | 96% | 79% |
| Speak Spanish | 0% | 2% | 13% |
| Race | Mathiston | Mississippi | National |
| White | 79.29% | 59.01% | 73.35% |
| Black | 17.18% | 37.51% | 12.63% |
| Asian | 0.15% | 0.96% | 5.22% |
| American Indian | 2.15% | 0.44% | 0.82% |
| Native Hawaiian | 0.00% | 0.02% | 0.18% |
| Mixed race | 1.23% | 1.18% | 3.06% |
| Other race | 0.00% | 0.88% | 4.75% |
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