| Index | Karnes City | Texas | National |
| Average Test Scores | 43% | 47% | 48% |
| Student/Teacher ratio | 12:1 | 14:1 | 16:1 |
| Total public schools | 5 | 7,418 | 79,221 |
| Total private schools | n/a | 1,267 | 24,874 |
| Total post-secondary schools | n/a | 463 | 7,963 |
| Index | Karnes City | Texas | National |
| Completed 8th grade | 73.7% | 79.3% | 84.3% |
| Completed high school | 68.4% | 77.8% | 83.0% |
| Completed some college | 37.4% | 57.3% | 59.4% |
| Completed associate degree | 18.8% | 34.9% | 38.5% |
| Completed bachelors | 14.0% | 28.1% | 30.3% |
| Completed masters | 3.5% | 9.6% | 11.5% |
| Completed professional degree | 1.0% | 2.6% | 3.3% |
| Completed doctorate | 0.2% | 1.1% | 1.3% |
There are a total of 5 public schools, n/a private schools and n/a post-secondary schools in Karnes City. Using the proficiency score averages, the average test scores for Karnes City, TX schools is 43%. The average student to teacher ratio is 12:1. In Karnes City, TX, an average of 73.7% of students have completed 8th grade and an average of 68.4% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Falls City, TX | 1,001 | 80% | 65.6% |
| Poth, TX | 1,805 | 68% | 42.4% |
| Kenedy, TX | 3,394 | 39% | 19.4% |
| Runge, TX | 1,192 | 32% | 32.8% |
| Karnes City, TX | 3,398 | 43% | 11.5% |
| City | Population | Avg. Test Scores | National Avg. |
| Frontenac, KS | 3,398 | 35% | 26.4% |
| Jena, LA | 3,400 | 80% | 67.4% |
| Haworth, NJ | 3,400 | 81% | 67.7% |
| Newcastle, WY | 3,395 | 55% | 13.5% |
| Kenedy, TX | 3,394 | 39% | 19.4% |
| Karnes City, TX | 3,398 | 43% | 11.5% |
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