| Statistic | Jefferson borough (Greene County) | Pennsylvania | National |
| Population | 252 | 12,801,989 | 328,239,523 |
| Population density (sq mi) | 1,341 | 287 | 91 |
| Median age | 43.5 | 40.6 | 37.7 |
| Male/Female ratio | 0.9:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 61% | 56% | 55% |
| Families w/ Kids under 18 | 37% | 40% | 43% |
| Speak English | 97% | 89% | 79% |
| Speak Spanish | 0% | 5% | 13% |
| Race | Jefferson borough (Greene County) | Pennsylvania | National |
| White | 99.21% | 81.37% | 73.35% |
| Black | 0.00% | 11.03% | 12.63% |
| Asian | 0.79% | 3.14% | 5.22% |
| American Indian | 0.00% | 0.20% | 0.82% |
| Native Hawaiian | 0.00% | 0.03% | 0.18% |
| Mixed race | 0.00% | 2.24% | 3.06% |
| Other race | 0.00% | 1.98% | 4.75% |
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