| Statistic | Holmesville | Ohio | National |
| Population | 287 | 11,689,100 | 328,239,523 |
| Population density (sq mi) | 1,289 | 288 | 91 |
| Median age | 32.7 | 39.3 | 37.7 |
| Male/Female ratio | 1.0:1 | 1.0:1 | 1.0:1 |
| Married (15yrs & older) | 66% | 56% | 55% |
| Families w/ Kids under 18 | 40% | 42% | 43% |
| Speak English | 83% | 93% | 79% |
| Speak Spanish | 8% | 2% | 13% |
| Race | Holmesville | Ohio | National |
| White | 100.00% | 82.16% | 73.35% |
| Black | 0.00% | 12.27% | 12.63% |
| Asian | 0.00% | 1.94% | 5.22% |
| American Indian | 0.00% | 0.19% | 0.82% |
| Native Hawaiian | 0.00% | 0.03% | 0.18% |
| Mixed race | 0.00% | 2.57% | 3.06% |
| Other race | 0.00% | 0.85% | 4.75% |
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