| Index | Hannibal | Missouri | National |
| Average Test Scores | 49% | 44% | 48% |
| Student/Teacher ratio | 11:1 | 14:1 | 16:1 |
| Total public schools | 10 | 1,899 | 79,221 |
| Total private schools | 2 | 531 | 24,874 |
| Total post-secondary schools | 2 | 213 | 7,963 |
| Index | Hannibal | Missouri | National |
| Completed 8th grade | 82.2% | 86.0% | 84.3% |
| Completed high school | 80.2% | 84.2% | 83.0% |
| Completed some college | 48.2% | 57.7% | 59.4% |
| Completed associate degree | 25.2% | 35.2% | 38.5% |
| Completed bachelors | 20.0% | 27.6% | 30.3% |
| Completed masters | 5.9% | 10.4% | 11.5% |
| Completed professional degree | 2.0% | 2.8% | 3.3% |
| Completed doctorate | 1.0% | 1.2% | 1.3% |
There are a total of 10 public schools, 2 private schools and 2 post-secondary schools in Hannibal. Using the proficiency score averages, the average test scores for Hannibal, MO schools is 49%. The average student to teacher ratio is 11:1. In Hannibal, MO, an average of 82.2% of students have completed 8th grade and an average of 80.2% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Frankford, MO | 452 | 70% | 45.8% |
| Palmyra, MO | 3,606 | 47% | 1.7% |
| Center, MO | 467 | 46% | 5.2% |
| Kinderhook, IL | 307 | 27% | 43.8% |
| Payson, IL | 1,398 | 25% | 49.0% |
| Hannibal, MO | 17,312 | 49% | 2.3% |
| City | Population | Avg. Test Scores | National Avg. |
| Shorewood, IL | 17,303 | 46% | 3.4% |
| Brenham, TX | 17,297 | 47% | 2.1% |
| Taylor, TX | 17,291 | 41% | 15.0% |
| Nederland, TX | 17,334 | 58% | 21.7% |
| Lindenwold, NJ | 17,288 | 17% | 65.4% |
| Hannibal, MO | 17,312 | 49% | 2.3% |
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