| Index | De Soto | Wisconsin | National |
| Average Test Scores | 44% | 41% | 48% |
| Student/Teacher ratio | n/a | 14:1 | 16:1 |
| Total public schools | n/a | 1,869 | 79,221 |
| Total private schools | n/a | 872 | 24,874 |
| Total post-secondary schools | n/a | 114 | 7,963 |
| Index | De Soto | Wisconsin | National |
| Completed 8th grade | 88.8% | 89.0% | 84.3% |
| Completed high school | 86.5% | 87.8% | 83.0% |
| Completed some college | 54.0% | 59.7% | 59.4% |
| Completed associate degree | 22.8% | 38.7% | 38.5% |
| Completed bachelors | 11.2% | 28.4% | 30.3% |
| Completed masters | 3.3% | 9.6% | 11.5% |
| Completed professional degree | 1.9% | 2.7% | 3.3% |
| Completed doctorate | 0.0% | 1.1% | 1.3% |
There are a total of n/a public schools, n/a private schools and n/a post-secondary schools in De Soto. Using the proficiency score averages, the average test scores for De Soto, WI schools is 44%. The average student to teacher ratio is n/a. In De Soto, WI, an average of 88.8% of students have completed 8th grade and an average of 86.5% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| New Albin, IA | 503 | 90% | 86.5% |
| Lansing, IA | 893 | 80% | 66.7% |
| Waukon, IA | 3,663 | 76% | 58.0% |
| Caledonia, MN | 2,759 | 58% | 21.5% |
| De Soto, WI | 514 | 44% | 8.3% |
| City | Population | Avg. Test Scores | National Avg. |
| Burlington, IL | 514 | 54% | 12.5% |
| Maddock, ND | 514 | 55% | 14.6% |
| Columbia, LA | 514 | 64% | 33.9% |
| Jayton, TX | 514 | 65% | 34.4% |
| Cawker City, KS | 514 | 55% | 14.6% |
| De Soto, WI | 514 | 44% | 8.3% |
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