| Index | De Soto | Missouri | National |
| Average Test Scores | 42% | 44% | 48% |
| Student/Teacher ratio | n/a | 14:1 | 16:1 |
| Total public schools | n/a | 1,899 | 79,221 |
| Total private schools | 1 | 531 | 24,874 |
| Total post-secondary schools | n/a | 213 | 7,963 |
| Index | De Soto | Missouri | National |
| Completed 8th grade | 77.5% | 86.0% | 84.3% |
| Completed high school | 73.7% | 84.2% | 83.0% |
| Completed some college | 48.1% | 57.7% | 59.4% |
| Completed associate degree | 27.3% | 35.2% | 38.5% |
| Completed bachelors | 13.5% | 27.6% | 30.3% |
| Completed masters | 5.3% | 10.4% | 11.5% |
| Completed professional degree | 0.2% | 2.8% | 3.3% |
| Completed doctorate | 0.0% | 1.2% | 1.3% |
There are a total of n/a public schools, 1 private schools and n/a post-secondary schools in De Soto. Using the proficiency score averages, the average test scores for De Soto, MO schools is 42%. The average student to teacher ratio is n/a. In De Soto, MO, an average of 77.5% of students have completed 8th grade and an average of 73.7% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Festus, MO | 12,054 | 59% | 23.1% |
| Potosi, MO | 2,572 | 59% | 22.9% |
| Herculaneum, MO | 4,081 | 56% | 16.7% |
| Cedar Hill, MO | 1,625 | 53% | 10.4% |
| Imperial, MO | 4,947 | 51% | 6.6% |
| De Soto, MO | 6,359 | 42% | 13.5% |
| City | Population | Avg. Test Scores | National Avg. |
| Dillon, SC | 6,358 | 36% | 24.8% |
| Burnet, TX | 6,357 | 38% | 21.6% |
| Ramtown, NJ | 6,354 | 65% | 35.9% |
| Johnsburg, IL | 6,354 | 40% | 16.0% |
| Brunswick, MD | 6,364 | 48% | 1.0% |
| De Soto, MO | 6,359 | 42% | 13.5% |
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