| Statistic | Clio | South Carolina | National |
| Population | 484 | 5,148,714 | 328,239,523 |
| Population density (sq mi) | 565 | 173 | 91 |
| Median age | 45.6 | 38.8 | 37.7 |
| Male/Female ratio | 0.7:1 | 0.9:1 | 1.0:1 |
| Married (15yrs & older) | 59% | 56% | 55% |
| Families w/ Kids under 18 | 15% | 40% | 43% |
| Speak English | 87% | 93% | 79% |
| Speak Spanish | 13% | 4% | 13% |
| Race | Clio | South Carolina | National |
| White | 26.03% | 67.27% | 73.35% |
| Black | 63.64% | 27.35% | 12.63% |
| Asian | 0.00% | 1.42% | 5.22% |
| American Indian | 5.99% | 0.32% | 0.82% |
| Native Hawaiian | 0.00% | 0.06% | 0.18% |
| Mixed race | 0.62% | 2.07% | 3.06% |
| Other race | 3.72% | 1.51% | 4.75% |
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