| Statistic | Carlisle | South Carolina | National |
| Population | 571 | 5,148,714 | 328,239,523 |
| Population density (sq mi) | 403 | 173 | 91 |
| Median age | 41.1 | 38.8 | 37.7 |
| Male/Female ratio | 0.6:1 | 0.9:1 | 1.0:1 |
| Married (15yrs & older) | 48% | 56% | 55% |
| Families w/ Kids under 18 | 43% | 40% | 43% |
| Speak English | 100% | 93% | 79% |
| Speak Spanish | 0% | 4% | 13% |
| Race | Carlisle | South Carolina | National |
| White | 7.36% | 67.27% | 73.35% |
| Black | 89.67% | 27.35% | 12.63% |
| Asian | 0.00% | 1.42% | 5.22% |
| American Indian | 0.00% | 0.32% | 0.82% |
| Native Hawaiian | 0.00% | 0.06% | 0.18% |
| Mixed race | 2.98% | 2.07% | 3.06% |
| Other race | 0.00% | 1.51% | 4.75% |
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