| Index | Cairo | Missouri | National |
| Average Test Scores | 53% | 44% | 48% |
| Student/Teacher ratio | n/a | 14:1 | 16:1 |
| Total public schools | n/a | 1,899 | 79,221 |
| Total private schools | n/a | 531 | 24,874 |
| Total post-secondary schools | n/a | 213 | 7,963 |
| Index | Cairo | Missouri | National |
| Completed 8th grade | 86.4% | 86.0% | 84.3% |
| Completed high school | 86.4% | 84.2% | 83.0% |
| Completed some college | 51.8% | 57.7% | 59.4% |
| Completed associate degree | 24.1% | 35.2% | 38.5% |
| Completed bachelors | 11.5% | 27.6% | 30.3% |
| Completed masters | 5.2% | 10.4% | 11.5% |
| Completed professional degree | 1.6% | 2.8% | 3.3% |
| Completed doctorate | 0.0% | 1.2% | 1.3% |
There are a total of n/a public schools, n/a private schools and n/a post-secondary schools in Cairo. Using the proficiency score averages, the average test scores for Cairo, MO schools is 53%. The average student to teacher ratio is n/a. In Cairo, MO, an average of 86.4% of students have completed 8th grade and an average of 86.4% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Huntsville, MO | 1,820 | 51% | 6.3% |
| Higbee, MO | 597 | 40% | 17.2% |
| Renick, MO | 151 | 40% | 17.7% |
| Clifton Hill, MO | 76 | 37% | 22.9% |
| Madison, MO | 422 | 36% | 25.3% |
| Cairo, MO | 230 | 53% | 10.9% |
| City | Population | Avg. Test Scores | National Avg. |
| Tennyson, IN | 230 | 65% | 35.4% |
| Blain, PA | 230 | 57% | 18.8% |
| Riggins, ID | 230 | 48% | 1.0% |
| Highwood, MT | 229 | 65% | 35.4% |
| McGrath, AK | 231 | 20% | 58.3% |
| Cairo, MO | 230 | 53% | 10.9% |
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